Isoxazolines like NexGard, Simparica and Bravecto are very important for tick prevention and appear safe to use. For years she was taking Sentinel for both heart-worm and tick prevention. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. Simparica Trio treats and protects against harmful parasites. . He had been taking the it for about 2-3 months. Simparica Trio is FDA-Approved and can be purchased with a prescription. It was very frightening. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. Is this true? And each monthly chewable tablet has a palatable liver . These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Second, Id like to ask a question if you dont mind. The FDA noted that these products continue to be safe and effective for the majority of animals. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Also, it is not recommended for use with other medications. I have a new Collie-mix with bi-coloured coat. I have a one year old Aussie mix. Hi Emily, Im leaning toward Frontline Plus based on what you wrote. Kills 5 types of ticks. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. GestorVet es el futuro de la gestin veterinaria. First, I want to thank you for the time and effort that went into writing this article. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. (Theres also a hyperlink to her article.) I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Approved for use in dogs over the age of 8 weeks and above 2.8 lbs, please note that depending on the pest . I found it extremely helpful & educational. Is Simparica trio safe for dogs with the MDR1 gene? Nexgard Spectra. THANK YOU, THANK YOU, THANK YOU! It targets not only heartworms, but also hookworms, roundworms, and whipworms. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. What are your thoughts on that? It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. Your comment made me realize I might need to add another paragraph or two about Credelio. Hi Emily . Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. I found some good information on the Cyphenothrin in Parastar Plus in this article. The vet thought he would be nice and put Advantage Multi on our cats. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! I disagree. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. Happy to help! It probably is the safest as it is aimed only at preventing heartworm. Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Thousands of dogs have experienced serious adverse reactions after taking . Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. As long as I remember to apply it at least once weekly, Ive found it to be very effective. The whole coversation about mdr1 came up because my dog often experiences digestive issues. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels. Simparica Trio 11.1-22 lbs. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. So called vet and they said topically we should try Parastar Plus. 1,9 And the fact is, dogs love both chews. Like Nexgard, Simparica needs to . When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. They said Frontline Plus doesnt really work anymore like it used too. Hi! It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. Simparica Trio is generally well tolerated at the recommended dose; adverse reactions (t ransient ataxia and/or muscle fasciculation in dogs with a deficient multidrug -resistance-protein 1 (MDR1 -/-)) are only seen at overdoses. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. Simparica TRIOse administra va oral una vez al mes, a una dosis de 1.2 mg de sarolaner/kg de peso corporal; . However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Giardia can be passed to and cause diarrhea in humans. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. Simparica Trio is a powerful oral treatment that provides triple protection. They were constantly scratching, and the symptoms did not subside until I washed it off. . So it really depends on the individual dogs, and you know your dogs best! In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. We gave her the first dose in late February and there were no adverse side effects for Sugar. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. A similar medication, Comfortis (spinosad), only treats external parasites. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. Thank you for the warning. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Thank you for fostering! I am going to try WonderCide as recommended by my Vet for fleas. Simparica Trio (133) 133 Reviews | Answered Questions. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Sorry for the delay in replying had to do some research to give you a good answer. Thank you! Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Its worth making a phone call to see what they would recommend for your pup. With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. Thank you again for all your help : ). On the downside, its efficacy only lasts for about a day. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Study free flashcards about heartworm extra note created by Dkamplain to improve your grades. 1 x 5mg tablet for 2.8 to 5.5 pounds. The majority of canines will be fine, but there are enough who will react. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. (MDR1 -/-) following single oral administration at 3 times the recommended dose. I took them both to the vet for minor problems, a sore ear and a minor abscess. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. Hi Emily, do you know if panacure is a safe wormer? Unless youre, say, an expat living in China, you can definitely find a better option. Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. 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