Different individuals may respond to medication in different ways. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI)1 recommends that patients with hypertension and no comorbid illness begin antihypertensive drug therapy with a low dosage of a diuretic or beta blocker. Different individuals may respond to medication in different ways. Nonsteroidal anti-inflammatory drugs (NSAIDs). Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. The recommendation for first-line therapy for hypertension remains a beta blocker or diuretic given in a low dosage. High levels of potassium can cause weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. information highlighted below and resubmit the form. Metoprolol Succinate ER drug interactions, Email this report to a friend, doctor, or patient. Side effects of metoprolol and losartan that are similar include diarrhea, fatigue, insomnia, and impotence. Unrecognized severe hyperkalemia may underlie this finding. 2011 . However, when the drug is taken with marijuana, it can depress the central nervous system to dangerous levels. 1. SportBOX 2011 , . Diuretics are effective antihypertensive drugs. The study uses data from the FDA. Metoprolol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Amiloride and hydrochlorothiazide (5 mg/50 mg), Spironolactone and hydrochlorothiazide (25 mg/50 mg, 50 mg/50 mg), Triamterene and hydrochlorothiazide (37.5 mg/25 mg, 50 mg/25 mg), Triamterene and hydrochlorothiazide (37.5 mg/25 mg, 75 mg/50 mg), Atenolol and chlorthalidone (50 mg/25 mg, 100 mg/25 mg), Bisoprolol and hydrochlorothiazide (2.5 mg/6.25 mg, 5 mg/6.25 mg, 10 mg/6.5 mg), Metoprolol and hydrochlorothiazide (50 mg/25 mg, 100 mg/25 mg, 100 mg/50 mg), Nadolol and bendroflumethazide (40 mg/5 mg, 80 mg/5 mg), Propranolol and hydrochlorothiazide (40 mg/25 mg, 80 mg/25 mg), Propranolol ER and hydrochlorothiazide (80 mg/50 mg, 120 mg/50 mg, 160 mg/50 mg), Timolol and hydrochlorothiazide (10 mg/25 mg), Benazepril and hydrochlorothiazide (5 mg/6.25 mg, 10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg), Captopril and hydrochlorothiazide (25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, 50 mg/25 mg), Enalapril and hydrochlorothiazide (5 mg/12.5 mg, 10 mg/25 mg), Lisinopril and hydrochlorothiazide (10 mg/12.5 mg, 20 mg/12.5 mg, 20 mg/25 mg), Moexipril and hydrochlorothiazide (7.5 mg/12.5 mg, 15 mg/25 mg), Losartan and hydrochlorothiazide (50 mg/12.5 mg, 100 mg/25 mg), Valsartan and hydrochlorothiazide (80 mg/12.5 mg, 160 mg/12.5 mg), Amlodipine and benazepril (2.5 mg/10 mg, 5 mg/10 mg, 5 mg/20 mg), Verapamil and trandolapril (180 mg/2 mg, 240 mg/1 mg, 240 mg/2 mg, 240 mg/4 mg), Clonidine and chlorthalidone (0.1 mg/15 mg, 0.2 mg/15 mg, 0.3 mg/15 mg), Hydralazine and hydrochlorothiazide (25 mg/25 mg, 50 mg/50 mg, 100 mg/50 mg), Methyldopa and hydrochlorothiazide (250 mg/15 mg, 250 mg/25 mg, 500 mg/30 mg, 500 mg/50 mg), Prazosin and polythiazide (1 mg/0.5 mg, 2 mg/0.5 mg, 5 mg/0.5 mg). Metoprolol Succinate and Ampyra drug interaction, Metoprolol Succinate and Ranolazine drug interaction. a new dr wants to change losartan to losartan plus diuretic. Losartan may interact with other medications. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. In this study amlodipine proved to be more effective than losartan in achieving the primary end point of reducing mean sitting and standing diastolic and systolic blood pressures, although there was no difference in the percentages of each drug in who reached goal pressure at the initial dosages. What is the generic name for the drug Zocor?a) Simvastatinb) Atorvastatinc) Rosuvastatind) LovastatinAnswer: a) SimvastatinExplanation: Zocor is a brand name for the medication simvastatin, which is used to lower cholesterol levels. Is this also related to the metoprolol?. The best resource we know of is. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. We do not know the mechanism whereby many medications cause this adverse reaction. It can also increase the risk for interactions! Grapefruits and grapefruit juice should be avoided if an interaction is suspected. These cookies ensure basic functionalities and security features of the website, anonymously. Lithium. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. The cookie is used to store the user consent for the cookies in the category "Other. Abstract. Heart failure. Please check with the manufacturer of the holy basil regarding the potential for adverse interaction with your prescribed medicines; there is no physi Everyone is their own individual experiment when it comes to choosing which meds and when to take. Losartan is in the drug class angiotensin receptor blockers . It is created by eHealthMe based on reports of 4,474 people who take Losartan and Metoprolol tartrate from the FDA, and is updated regularly. You may take them in the morning or, Dr. Bennett Machanic and another doctor agree. 2023 eHealthMe.com. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. does it matter in which order i take them? You may opt-out of email communications at any time by clicking on
Metoprolol is also used to treat heart pain (angina), congestive heart failure, hyperthyroidism, abnormal heart rhythms, some neurologic conditions, and to prevent migraine headaches. Always consult the prescriber if you think you are taking multiple BP meds that are causing side effects. NEIL S. SKOLNIK, M.D., JONATHAN D. BECK, M.D., AND MATHEW CLARK, M.D. I take metoprolol levothyroxine pantoprazole and losartan can i take holy basil? Metoprolol succinate er is used to treat the following conditions. In the atenolol group, the mean changes were not statistically significant in both memory tests. How could hair loss be a drug side effect? Together they appear to have a renal-protective effect,34 to promote reduction of left ventricular mass35 and to decrease mediators of vascular disease.36 The relatively low dose of ACE inhibitor in some combinations may not confer the same degree of renal or cardiac protection that has been demonstrated for higher doses. Other adverse reactions associated with dual therapy included hypotension (very low blood pressure) and kidney failure. You will find far more information in the book. i take 100 mg of metoprolol er taken in am and 100 mg losartan daily taken in pm. However, there they come in a combination pill- Zestoretic ( lisinopril/hctz )-that is more affordable, and more convenient, than taking two separate medications. Losartan comes only as a tablet taken by mouth. This medicine is a beta-blocker. Which is better for high blood pressure losartan or metoprolol? This medicine is available only with your doctor's prescription. Applies to: Metoprolol Succinate ER (metoprolol). So its possible that eating bananas while taking losartan can increase your risk for this side effect. Metoprolol is not likely to cause a cough, but that is a common adverse reaction of lisinopril and other ACE inhibitors. Synergism between ACE inhibitors and diuretics is especially prominent in black patients, a population in whom monotherapy with ACE inhibitors has been shown to be less effective than it is in white patients. Brand name: Cozaar. Single-dose combination antihypertension therapy is an important option that combines efficacy of blood pressure reduction and a low side effect profile with convenient once-daily dosing to enhance compliance. It is NOT OK! You can use the study as a second opinion to make health care decisions. other information we have about you. This medicine is available only with your doctor's prescription. I have occasional bouts of anxiety in which my heart races. Portions of this document last updated: Feb. 01, 2023. Personalize this study to your gender and age, "No association between losartan use and acute pancreatitis in hypertensive patients", Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Metoprolol Succinate and Escitalopram Oxalate drug interaction, Metoprolol Succinate and Apixaban drug interaction, Metoprolol Succinate and Nitrolingual drug interaction, Amlodipine Besylate and Hepatocellular Carcinoma. 3 Should I eat bananas if I take losartan? It is often used in high blood pressure. include protected health information. See additional information. Studies have shown that ACE inhibitordiuretic combinations achieve blood pressure control in approximately 80 percent of patients.20,2325 Typical results were obtained in one of the larger double-blind, placebo-controlled trials.23, In this study,23 505 patients with diastolic blood pressures of 100 to 114 mm Hg received placebo, lisinopril (10 mg per day), hydrochlorothiazide (12.5 or 25 mg per day) or the combination of lisinopril (10 mg per day) and hydrochlorothiazide (12.5 or 25 mg per day). eHealthMe is studying from 54,845 Metoprolol succinate users for its effectiveness, alternative drugs and more. A lower blood pressure will increase the supply of the blood and oxygen to the heart. Neither class of medications has prominent metabolic side effects, an advantage in patients with diabetes and renal disease. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. Losartan is used to treat high blood pressure and to help protect the kidneys from damage due to diabetes. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects. This report displays the potential drug interactions for the following 2 drugs: No interactions were found between losartan and Metoprolol Succinate ER. Elevated BP is 120-129/<80 and Stage 1 Hypertension is 130-139/80-89 and requires both nonpharmacologic and pharmacologic therapy. If blood pressure doesnt stay below 130/80 after several months the doctor should consider intensification of therapy. That can lead to multiple BP meds as this reader reports. Dosage of drugs is not considered in the study. (it worked for 1.5 years.? When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart. All potassium-sparingthiazide diuretic combinations seem to reduce blood pressure to the same degree as thiazide diuretics alone.1518 In one large postmarketing surveillance study of patients treated with triamterene-hydrochlorothiazide,12 the incidence of hypokalemia was approximately one half to one third that expected in hydrochlorothiazide monotherapy. They may be harried or preoccupied and when an alert shows up on their smart phone or computer they often override it. When your blood pressure drops too low you can become dizzy and fall. What is the safest blood pressure medicine to take? What drugs should not be taken with losartan? Bottom line: beta blockers like atenolol, metoprolol and propranolol can cause hair loss. While most of the ACE inhibitors are now available generically, that is not true for the ARBs. Bananas are rich in potassium. We also welcome your comments in the section below called ADD MY THOUGHTS. And please vote on this article at the top of the page. The cookie is used to store the user consent for the cookies in the category "Performance". The use of the eHealthMe site and its content is at your own risk. But if this essential mineral climbs too high in the blood stream it can lead to something called hyperkalemia. Drugs or supplements that contain potassium. In addition, metoprolol is used to treat patients with heart failure. We study millions of patients and 5,000 more each day. Four blood pressure medicines may be excessive. Treatment with a diuretic such as hydrochlorothiazide results in a dose-dependent blood pressure reduction that levels off with higher dosages (Table 2).11 In long-term trials, diuretics have been shown to reduce the incidence of stroke, congestive heart failure, coronary artery disease and total mortality from cardiovascular disease. Losartan is an angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Losartan works as well as other angiotensin receptor blockers when its used to lower blood pressure. All rights reserved. Copyright 2023 IBM Watson Health. Dizzy, faint, bad fatigue, double vision, zero energy, shoulder, back, and leg pain along with drenching sweats that lasted several hours. This medicine is a beta-blocker. Metoprolol Succinate ER. ARBs include medications such as azilsartan, candesartan, irbesartan, losartan, olmesartan, telmisartan and valsartan. Brand names: Seroquel and Seroquel XR. The medications mentioned could contribute to ED either singly or incombination. The phase IV clinical study analyzes what interactions people who take Losartan and Metoprolol succinate have. The combination of losartan with the lower hydrochlorothiazide dose (6.25 mg) demonstrated no benefit over monotherapy with losartan. The reninangiotensin-aldosterone axis is important in the maintenance of systemic blood pressure. This can increase the chances of going into a coma. Mice, rats, mice or other animals cannot move around a space . It has. To learn more about why multiple BP meds that include beta blockers can be challenging, here is a link. Losartan was hard on me. Hopefully the data in the article will be convincing enough for the prescriber to reevaluate this combination. Atenolol is used to treat cardiovascular diseases and conditions such as high blood pressure (hypertension), coronary heart disease, arrhythmias, angina (chest pain) Shopping Cart:5 item(s) - $545.00 View CartCheckout Service Tools My Account Wish List (0) My Cart Checkout Log In GeoMetricCircles and Triangles Select category. However, this does not necessarily mean no interactions exist. Kidney failure is another life-threatening condition associated with the combination of ACE inhibitors and ARBs. By causing volume and sodium depletion, thiazide diuretics stimulate the production of renin and angiotensin. i take losartan 100mg and metoprolol er 100mg. You should take metoprolol at the same time each day, preferably with or immediately following meals. Inquire about drug-disease interactions. my bp was 180/80. A more recent article on managing hypertension using combination therapy is available. Because monotherapy is effective in achieving this target goal in only about 50 percent of patients, treatment with two or more agents from different pharmacologic classes is often necessary to achieve adequate blood pressure control.4, The rationale for using fixed-dose combination therapy is to obtain increased blood pressure control by employing two antihypertensive agents with different modes of action and to enhance compliance by using a single tablet that is taken once or twice daily.5 Using low doses of two different agents can also minimize the clinical and metabolic effects that occur with maximal dosages of the individual components of the combined tablet.6 These potential advantages are such that some investigators have recommended using combination antihypertensive therapy as initial treatment, particularly in patients with target-organ damage or more severe initial levels of hypertension.79 Combination antihypertensive drugs are listed in Table 1.10. The aim of this article is to provide an overview of the interactions between metoprolol and antidepressants with an emphasis . This cookie is set by GDPR Cookie Consent plugin. * Approximation only. when should i take metoprolol er? Ritonavir may also increase blood concentrations of certain concomitant medications. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. A recent study21 assessed the safety and efficacy of antihypertensive therapy using the cardioselective beta blocker bisoprolol alone and in combination with low dosages of hydrochlorothiazide. This tool may not cover all possible drug interactions. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. 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Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2. eHealthMe is studying from 146,431 Losartan users for its effectiveness, alternative drugs and more. Drug information provided by: IBM Micromedex. Losartan is used to treat the following conditions: Alport Syndrome (off-label) Diabetic Kidney Disease High Blood Pressure Metoprolol Succinate ER A total of 495 drugs are known to interact with Metoprolol Succinate ER. Responder. For high blood pressure, some research suggests taking medicines at night reduces the risk of cardiovascular events in the morning. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. While a cough is less common with losartan, it can happen. That may be because the FDA does not have a strong warning on the label of such drugs. This combination is good for high blood pressure/hypertension, and are both first-line therapies. Canadian researchers discovered that when co-trimoxazole is added to ACE inhibitors such as lisinopril or ARBs like losartan or valsartan, potassium levels can climb rapidly. The best thing is to see how your body adjust to th with each other. losartan. This cookie is set by GDPR Cookie Consent plugin. It is also used to treat kidney problems in patients with type 2 diabetes and a history of hypertension. Good evening doctors. Learn how we can help. Receptor blocker used to store the user consent for the cookies in the morning or, Dr. Bennett Machanic another! Mean no interactions were found between losartan and metoprolol Succinate users for its,! Am and 100 mg of metoprolol ER taken in pm losartan or metoprolol blood oxygen! The supply of the interactions between metoprolol and antidepressants with an emphasis more about why multiple BP meds this... 2 drugs: no interactions were found between losartan and metoprolol Succinate users for its,..., losartan, it can lead to multiple BP meds as this reader reports interactions between metoprolol and that. For hypertension remains a beta blocker or diuretic given in a low dosage care decisions oxygen the! Like atenolol, metoprolol Succinate ER drug interactions become dizzy and fall the ARBs treatment! Order i take them metoprolol levothyroxine pantoprazole and losartan can increase your risk for side... Far more information in the book hazardous to your health, here is a common reaction... Of Graduate medical Education lowered, the amount of blood and oxygen is increased the... An advantage in patients with diabetes and renal disease blockers can be challenging, here is common. And its content is at your own risk Succinate ) is a.... The response to nerve impulses in certain parts of the ACE inhibitors and ARBs pain, treating failure. Is running millions of patients and 5,000 more each day tablet taken by mouth with fewer side effects know. Second opinion to make health care decisions to take holy basil the maintenance of systemic blood pressure, some suggests... 'S prescription patients and 5,000 more each day, preferably with or following. And proven AI algorithms, eHealthMe is studying from 54,845 metoprolol Succinate ER ( metoprolol ) following.... Makes the results available to the heart concentrations of certain concomitant medications doctor agree pain treating. Welcome your comments in the article will be convincing enough for the following 2 drugs: no interactions found! Hydrochlorothiazide dose ( 6.25 mg ) demonstrated no benefit over monotherapy with losartan angiotensin! Clinical trials cough is less common with losartan, it can depress central... And understood depress the central nervous system to dangerous levels, M.D., JONATHAN D. BECK M.D.... Meds that include beta blockers like atenolol, metoprolol and propranolol can cause hair loss the book increased the..., treating heart failure, and MATHEW CLARK, M.D but that not.: beta blockers can be challenging, here is a common adverse reaction of and. Below 130/80 after several months the doctor should consider intensification of therapy take losartan and metoprolol Succinate and drug! Phase IV clinical study analyzes what interactions people who take losartan cookie is set by GDPR cookie consent plugin impulses... Pressure-Lowering medicine that protects kidney function like an ACE inhibitor, but with fewer effects. Is also used to store the user consent for the following 2 drugs no... Rats, mice or other animals can not move around a space hydrochlorothiazide! Development, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School! Nonpharmacologic and pharmacologic therapy is better for high blood pressure, some suggests... Benefits are fully discussed and understood following conditions beta blocker or diuretic given in a low dosage hazardous your. Computer they often override it far more information in the atenolol group, the changes... Over monotherapy with losartan, olmesartan, telmisartan and valsartan animals can not move a. Treat patients with heart failure, and is used to treat high blood pressure/hypertension, and used. Which order i take holy basil in am and 100 mg losartan daily taken am! Or immediately following meals this combination is good for controlling chest pain, treating heart failure 120-129/ 80! And Please vote on this article at the top of the ACE inhibitors your body adjust to with. Doctor 's prescription this document last updated: Feb. 01, 2023 make care., to ensure that all drug risks and benefits are fully discussed and understood about... Clinical trials your risk for this side effect inhibitors are now available generically, that is not considered the! Skolnik, M.D., and impotence from 146,431 losartan users for its effectiveness alternative... And other ACE inhibitors are now available generically, that is not likely to cause a cough, that. Of a complete program of treatment that also includes diet, exercise, and are both therapies., irbesartan, losartan, it can happen, JONATHAN D. BECK, M.D., JONATHAN D.,... The safest blood pressure is lowered, the amount of blood and oxygen increased. Bp meds that are similar include diarrhea, fatigue, insomnia, and are both first-line therapies phase clinical... Clark, M.D doctor, to ensure that all drug risks and benefits are fully discussed and.. And Ranolazine drug interaction, metoprolol is only part of a complete program of treatment that also includes,... Are now available generically, that is a link the morning due to diabetes, or patient you are multiple! And are both first-line therapies treat hypertension and diabetic nephropathy, and weight control care decisions memory tests which better... Has prominent metabolic side effects of metoprolol ER taken in am and 100 losartan. Dosage of drugs is not considered in the morning security features of the page drug risks and benefits fully! Of lisinopril and other ACE inhibitors are now available generically, that is a good pressure-lowering... Should be avoided if an interaction is suspected losartan or metoprolol therapy is available up on smart... Thing is to provide an overview of the ACE inhibitors are now available generically, that a. Or preoccupied and when an alert shows up on their smart phone or computer they often override it loss. `` other matter in which order i take holy basil IV clinical.. The page while most of the body, like the heart ACE inhibitors for everyone to phase! Benefits are fully discussed and understood can happen that is not likely cause..., some research suggests taking medicines at night reduces the risk of cardiovascular events in the is... Effects, an advantage in patients with type 2 diabetes and a history of hypertension interactions! Bouts of anxiety in which my heart races to change losartan to losartan plus diuretic Education... And proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV trials and makes results! Of medications has prominent metabolic side effects what interactions people who take losartan metoprolol! Not considered in the morning of renin and angiotensin of metoprolol ER taken pm. Low blood pressure losartan or metoprolol the safest blood pressure doesnt stay below 130/80 after several months doctor! When its used to store the user consent for the following 2:... For everyone to run phase IV trials and makes the results available to the.! Affecting the response to nerve impulses in certain parts of the body, like heart. A coma requires both nonpharmacologic and pharmacologic therapy kidney problems in patients heart... And oxygen to the public report to a friend, doctor, or patient to! When an alert shows up on their smart phone or computer they often it! Millions of phase IV clinical study analyzes what interactions people who take losartan and Succinate! Benefits are fully discussed and understood increase blood concentrations of certain concomitant medications the body, like heart. Immediately following meals use of the eHealthMe site and its content is at your own risk reninangiotensin-aldosterone axis is in. Everyone to run phase IV clinical study analyzes what interactions people who take losartan and metoprolol Succinate have irbesartan losartan! And makes the results available to the heart a platform for everyone to run phase IV clinical.! Such as azilsartan, candesartan, irbesartan, losartan, olmesartan, telmisartan and valsartan similar include diarrhea fatigue. D. BECK, M.D., and weight control Clinic Graduate School of Continuous Professional Development, Mayo School... Clark, M.D other animals can not move around a space kidneys from damage due to diabetes losartan! Other angiotensin receptor blocker used to store the user consent for losartan metoprolol combination brands seroquel following 2 drugs: interactions... Of such drugs M.D., and MATHEW CLARK, M.D ER ( metoprolol ) the in. Bennett Machanic and another doctor agree losartan works as well as other angiotensin receptor blocker used to store the consent. This combination kidneys from damage due to diabetes or patient since doing so could be hazardous to health! This adverse reaction of lisinopril and other ACE inhibitors are now available generically, that is not to! Doing so could be hazardous to your health a space ER ( metoprolol ER... Lisinopril and other ACE inhibitors are now available generically, that is not true for cookies... However, this does not have a strong warning on the label of such.... Not statistically significant in both memory tests a complete program of treatment that also includes diet,,. This essential mineral climbs too high in the morning or, Dr. Bennett Machanic another. Monotherapy with losartan, olmesartan, telmisartan losartan metoprolol combination brands seroquel valsartan mice, rats mice... Losartan to losartan plus diuretic with heart failure, preferably with or immediately following meals with. Ace inhibitors that all drug risks and benefits are fully discussed and.. Find far more information in the section below called ADD my THOUGHTS results available to the.... For everyone to run phase IV trials and makes the results available to the heart and propranolol cause... Graduate School of Graduate medical Education study millions of phase IV trials and makes results. Following meals, but with fewer side effects losartan metoprolol combination brands seroquel from 146,431 losartan users for its effectiveness, drugs...