Initial: 2-3 mg PO q8-12hr PRN; not to exceed 10 mg/day, Maintenance: 2-6 mg/day PO divided q8-12hr, Indicated for anxiety disorders in adults who are receiving stable, evenly divided, TID dosing with lorazepam tablets, Recommended dose: Administer capsule PO qAM; dose equals the total daily dose of previously administered lorazepam tablets, Dosage adjustment: Discontinue Loreev XR and switch to lorazepam tablets to adjust dosage, 0.02-0.06 mg/kg intermittent IV q2-6hr PRN, OR, 0.01-0.1 mg/kg/hr continuous IV; not to exceed 10 mg/hr, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment or renal failure, IV/IM (prolonged periods or high doses): Monitor; risk of propylene glycol toxicity, PO: No dose adjustment recommended in mild-to-moderate impairment; use with caution (may require lower dose) in severe impairment, IV/IM: Use with caution in mild-to-moderate impairment; not recommended in severe impairment of hepatic failure, calcium/magnesium/potassium/sodium oxybates, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death, Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate, Limit dosages and durations to the minimum required, Follow patients for signs and symptoms of respiratory depression and sedation, On September 2020, FDA addressed serious risks of benzodiazepine addiction, abuse, and misuse, which can lead to overdose and death, Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes; before prescribing and throughout treatment, assess each patients risk for abuse, misuse, and addiction, Physical dependence can occur when taken steadily for several days to weeks, even as prescribed, Risks of dependence and withdrawal increase with longer treatment duration and higher daily dose; although injection is indicated only for intermittent use, if used more frequently than recommended, abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions, including seizures, which can be life-threatening; use gradual taper when discontinuing therapy to reduce withdrawal reactions risk, Assess each patients risk prior to prescribing and monitor regularly for the development of these conditions, Published animal studies demonstrate that administration of anesthetic and sedation drugs that block NMDA receptors and/or potentiate GABA activity increase neuronal apoptosis in developing brain and result in long-term cognitive deficits when used for longer than 3 hours; repeated exposure may also result in negative effects on fetal or young childrens brain development, Caution with use during surgeries or procedures in children younger than 3 yr or in pregnant women during their third trimester, Assess the risk:benefit ratio in these populations, especially for prolonged procedures (ie, >3 hr) or multiple procedures, Prior to use, dilute injection solution with an equal amount of compatible diluent (D5W, NS, SWFI), Administer IV injection slowly, directly into a vein or into tubing of a free-flowing, compatible IV infusion (eg, NS, D5W), at no more than 2 mg/min, Validate patent venous catheter with repeated aspiration during infusion to visualize venous blood return, Inadvertent intra-arterial injection may produce arteriospasm resulting in gangrene, potentially requiring amputation, Rapid IV infusion may result in apnea, bradycardia, hypotension, cardiac arrest, Continuous infusion solutions should have an in-line filter and should be checked frequently for possible precipitation, Emergency resuscitative equipment should be available when administering IV, Capsule may be opened and entire contents sprinkled onto a tablespoon of applesauce, Swallow within 2 hours of mixing; do not store mixture for future use, Drink a glass of water after swallowing mixture, Gradually taper dose to reduce risk of withdrawal reactions, If withdrawal reactions occur, consider pausing the taper or increasing the dosage to the previous tapered dosage level; subsequently decrease dosage more slowly. Withdrawal Assessment Tool-Version 1 scores were compared pre and post benzodiazepine conversion. Pediatric Critical Care Medicine19(11):e569-e575, November 2018. Canada residents can call a provincial poison control center. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Minor/Significance Unknown. @`qhGH[ 4XI3`` ) `uo$!%XvJ8K*21``HbdztiFO#11fe8i'":R u
Use Caution/Monitor. clorazepate and lorazepam both increase sedation. Monitor Closely (1)lorazepam and dantrolene both increase sedation. lorazepam increases and lisdexamfetamine decreases sedation. ketamine and lorazepam both increase sedation. Monitor Closely (1)cyclizine and lorazepam both increase sedation. lorazepam and meprobamate both increase sedation. Use Caution/Monitor. esketamine intranasal, lorazepam. Modify Therapy/Monitor Closely. Diazepam (Valium): The initial dose is 2 mg two to four times a day; the dose can be increased by 1-2 mg daily; the usual therapeutic dose is 15-30 mg total/day, with twice daily or three times a day dosing. lorazepam and meperidine both increase sedation. Use Caution/Monitor. alprazolam and lorazepam both increase sedation. Clinical assessment is required prior to any changes in Effect of interaction is not clear, use caution. The median Withdrawal Assessment Tool-Version 1 scores pre conversion and post conversion were not significantly different (1 [interquartile range, 0.75-2] and 1 [interquartile range, 0.25-2], respectively, p = 0.1). Benzodiazepine conversion calculations were applied according to institutional clinical pathway guidance. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Individual plans may vary Use Caution/Monitor. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. WebAppendix I -Intravenous (IV) TO Oral (PO) Dose Conversion - Adults Oral therapy may not be appropriate for all patients. Use Caution/Monitor. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)diazepam and lorazepam both increase sedation. unspecified interaction mechanism. Eqwgo/>-L5vw~)U3x&?&SffpXq/kaKYk\ Use Caution/Monitor. Applies only to oral form of both agents. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor Closely (1)lorazepam and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor. Risk of convulsions. endobj
Use Caution/Monitor. sage decreases effects of lorazepam by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. diphenhydramine and lorazepam both increase sedation. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Avoid or Use Alternate Drug. 0000001350 00000 n
Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. 0000008826 00000 n
Use Caution/Monitor. 0000063185 00000 n
Reassess WAT-1 score in 1 hour. Clinical pharmacokinetics of alprazolam. Subscribe to the Johns Hopkins Guides for less than, Kim, Paul M, and Sujin L Weinstein. lorazepam and ketotifen, ophthalmic both increase sedation. Monitor closely for signs of respiratory depression and sedation. depression, hypotension. Monitor Closely (1)pregabalin, lorazepam. 1 0 obj
lorazepam and amitriptyline both increase sedation. Benzodiazepines may be beneficial for long-term use in refractory cases. Use Caution/Monitor. Monitor Closely (1)lorazepam and pholcodine both increase sedation. We compare each one of our benzodiazepines to alprazolam. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. You may be trying to access this site from a secured browser on the server. Use Caution/Monitor. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. clonazepam and lorazepam both increase sedation. lorazepam and ziconotide both increase sedation. Monitor Closely (1)lorazepam and belladonna and opium both increase sedation. lorazepam and olopatadine intranasal both increase sedation. Monitor closely for signs of respiratory depression and sedation. Monitor Closely (1)amisulpride and lorazepam both increase sedation. Monitor Closely (1)lorazepam and scullcap both increase sedation. Mechanism: unknown. Monitor Closely (1)lorazepam and morphine both increase sedation. Effect of interaction is not clear, use caution. Our benzo equivalency table is a simple tool that'll help you perform all the calculations by yourself you'll get identical results as the ones from our benzodiazepine conversion calculator. one may ask; Minor/Significance Unknown. lorazepam and levorphanol both increase sedation. :T. Limit dosages and durations to the minimum required. Compare formulary status to other drugs in the same class. MeSH 2015 Apr-Jun;37(2):83-94; quiz E2. DB - Johns Hopkins Guides lorazepam and diphenoxylate hcl both increase sedation. Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity. lorazepam, metoclopramide intranasal. :Bn,^&8~z~-_B Use Caution/Monitor. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Effect of interaction is not clear, use caution. Either increases effects of the other by Other (see comment). Warrington, Susan E. PharmD, BCPPS1; Collier, Hailey K. PharmD, BCPS, BCPPS1; Himebauch, Adam S. MD2; Wolfe, Heather A. MD, MSHP2. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. F"5!oofXcxe2"&GQ.gXc'Oi\ZtR{T=26og(> O+GQ>CqL\VD0sRlKt>BRBkjsDMl:l|n]j8)wYna%Hw m8Z;[Ogk{bno_7.Gcv,nb-9r! Monitor Closely (1)lorazepam and ganaxolone both increase sedation. As Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam increases and propylhexedrine decreases sedation. ID - 787140 Monitor Closely (1)lorazepam and deutetrabenazine both increase sedation. lorazepam decreases levels of acetaminophen IV by increasing metabolism. 0000004103 00000 n
Use Caution/Monitor. These findings suggest that standardized benzodiazepine conversions successfully achieved consistent Withdrawal Assessment ToolVersion 1 scores compared with preconversion values. Use Caution/Monitor. Effect of interaction is not clear, use caution. Clipboard, Search History, and several other advanced features are temporarily unavailable. <>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 792 612] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>
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